It depends. If it's a quick check and water, about 1.5 hours; if it's feeding day, I stagger it between 5 days, 7 days, 13 days and each feeding day takes about 2.5 hours from pulling out of the freezer to checking for refusals; spot cleaning 2.5 hours, major messes anywhere from 4-6 hours; serious cleaning takes entire weekends.
But I have quite a few snakes.