For ball pythons it started with albino back in the early to mid 90's i believe. Over the years they slowly started to discover more and more. Some of the earliest gene's are pastel, pied bald, spider, yellow belly, hypo, caramel albino among others. And the first combo "designer ball" python heck for any reptile species was the bumble bee back in 2001 which is spider x pastel. Every year they find albino, hypo and yellowbellies in the wild but they've only ever found one spider to date. Its crazy to think all these spider ball pythons we see today all came from just one. Also imagine if spider was never discovered. Imagine no bumble bee's no killer bee's just no bee's lol. I should mention i'm getting most of this out of the ultimate morph maker guide so if anyone disagrees with any of this info take it up with kevin mccurley at nerd lol. I do believe and trust him. He's been breeding ball pythons for a long time.