I haven't gone with the vacuum sealer yet, but am considering it. I did just weigh, sort and bag 125 feeders in small quantities though. This way I'm only opening each bag a few times while the rest remain sealed up nice and tight until I need them.
As far as refusals, my Kingsnake, Django, is a beast and will eat any refusals from my BP. If for some reason he refused as well, I would just throw it in the yard, something would eat it. At least the prey didn't die for nothing, something will get a meal out of it.