Mites will not become resistant to PAM. PAM is basically a poison. It will kill mites, snakes, people and pretty much anything. You're not going to build up a tolerance for it like you could with antibiotics.

PAM is awesome if used correctly. Problem is a lot of people think 'there isn't much coming out, so lets spray the heck out of stuff'. That's where problems start. A little goes a long way on that stuff. You don't need to spray daily. To get rid of mites, I use it weekly or even 2 weeks depending if the snake doesn't piss or poop all over the paper towels.

And like I said, I talked to Bob at Pro Products about the stuff. He said the only reason they said lasts 2 weeks is because when they applied for their registration through the EPA, it showed a 2 week residual on outdoor komodo dragon sand pits with rain. In a much less harsh environment like a house, he said it lasts at least 30 days. He said they actually find it to be effective for several months indoors.

There are lots of people who use Nix, Hot Shot no pest strips, olive oil and all other kinds of home remedies but you know, I would rather trust something 'made' for reptile use over some so called 'home remedy'. And for the love of god, don't listen to people who use those Hot Shot no pest strips hung next to a cage with the animals still in it. You can read right on the box it says not safe for anything in the room.