I do an AM and PM check on all animals, every day, to clean enclosures and change water as needed. Probably averages out to about 1 hour each day. Being meticulous when it comes to cleaning waste and keeping water fresh is probably the greatest ingredient for healthy reptiles.
Thursday: Pull feeders from the freezer and put them in the fridge to prepare for Friday feeding. Some of the more active colubrids might get a midweek meal, usually just a fresh killed mouse since I always have them on hand.
Friday: Normal feeding night, roughly 1/2 of the animals are offered food depending on their build and/or the season. I run a late PM check a couple hours later and if any meals are uneaten, they go to one of my garbage disposal critters.
Sunday: Rodent cleaning day. I only run 3 breeding colonies of mice these days so it's a quick affair. I usually have 15-20 growouts that get euthanized and frozen during cleaning. Sunday is also my fresh water day for the herps. Every bowl gets a good scrub out - even if it was just changed the previous day during AM or PM rounds.