Have you watched any handling videos ? I found them helpful. Once you become accustomed to the snakes moods/movements you will know when a good time is to grab them. Never grab or reach near face always try to give rub then pick it up by the tail and support the fattest bits...mine feels secure when it's anchored to something then once it relaxes it will relax the whole body.
What is it doing that makes you think it's not okay with being picked up? Did it strike?