I don't feed frozen thawed (fresh kill only) so I've never experienced anything like that before. But the day after feeding I go through all my tubs and check for uneaten rodents and spray down the substrate with water, spot clean, and change out their water. Mainly I just want to be sure there are no uneaten rodents that will go bad. I try not to disturb the snakes at all right after they have eaten because I don't want to chance regurgitation, I'll wait until the next morning to clean things up. If you can spot clean immediately without disturbing the snake I'd go ahead with it right away.
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