I have a colony of 10.60
To give you an idea I have just brought in some new blood after not doing so for 7 years and my colony is strong and without any issue (I did it because I want to breed some hairless so I bought a pair of those), of course if you have issues bringing new blood and culling animals with issue is a must, just be careful and make sure that you quarantine any new stocks.
Sometime bring in new blood can cause a lot more issues than selective and line breeding.
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