#1 is keeping the people that know where you keep your snakes to a minimum. Most people that steal snakes know about snakes. Most people that keep pricey stuff tend to keep their collection hush-hush. The more people you invite over to see your collection....the higher chance of someone doing something shady. If you share info or pictures online, don't give someone a roadmap right to your snake room.
As a deterant to some un-snakewise burglar that may enter your house/snake building......a few Python warning signs, video surveillance or venomous snake signs may work well. You can also get those single door alarm chimes from home depot for a 20-30 bucks that will make someone think they are getting busted..