Well for one thing, it smells - at least with colubrids. I know when I need to clean, even if I can't see it. "Bio-active" is not any kind of excuse either. I use fish water for fertilizing the plants. All snake waste and dirty substrate gets scooped as soon as I know about it.
I'm not the world's fussiest housekeeper, but still...When we had a cat, the litter box was scooped as soon as it was used. I can't stand that sort of filth, nor the smell. I clean the rat CritterNation daily, and I clean up after the canary and budgies daily too. Yes, it takes time, but that is part of living with animals.