That IS a early sign of a RI. And while she will not "always" have it once she did...she might be more susceptible to it. Especially if it wasn't eradicated all the way.

I'm not sure what you mean with her not responding to medication well.

If you get her the correct medication, she will respond. Because it will eradicate the infection if you give it correctly and long enough. However, getting the correct medication is the key.

The vet needs to take a culture and test which medication actually works. Not every medication works on every RI. Since this seems to be an ongoing problem, make sure you take her to a experienced reptile vet. Ask about a culture. Ask about how LONG you should be giving the meds...

Its frustrating for sure, but treating blindly (without culture) can be hit or miss..