I'm assuming you have her in a glass tank? Coco husk or coco fiber substrate retains humidity very well. Aspen is a drying substrate.

If you have a screen top, you can also cover most of the top with a wet towel. It'll help, just not look pretty.

Two of my ball pythons never ball up- I've never seen it in their life, even when they were a hatchling.

How often are you handling her? There is a "too often", depending on the individual snake, which creates more stress for the bp. Handling just 10~20 minutes a day, a couple days a week, is even fine. If she's a hatchling, they are just more scared and defensive, but will naturally become calmer and easygoing as they mature.

feel free to post pics of the enclosure!