Yeah it just depends on the snake. When I had about a dozen I thought I had them figured out pretty well as being mostly laid back and used to me. After another couple dozen, I've learned some are just jerks from hatchlings even when you know husbandry is spot on and to just enjoy how they look. I dont think any of my snakes really care who exactly is picking them up. I also have the most aggressive milk snake I've ever seen. Had her since she was a hatchling and handled her a lot but she's still super wirey at 5 years old and will randomly bite me after I've had her out for a few minutes.