I honestly don't think the number of spiders that fail to thrive/need to be culled compares to the number for Caramel, or the number of pearls that fail to thrive, or the number of ball pythons with underbites/sharkmouth which fail to thrive. Honestly I think wobble is one of the less severe problems with ball python breeding.
Heck, consider how many normals are likely culled each year by less moral breeders who don't want to be stuck with snakes which are less desirable.
Personal preference may shy one away from certain genetic lines for associated downsides, but realistically it's not like we're talking about pure breed dogs which have horrific genetic defects that appear over their lives, leading to putting them down.