My ball has always hissed, since the day I got her. She's all hiss and no action though. I lift her hide up, and softly pet her back a bit to let her know it's me. That first pet, she always lets out a cute little hiss. So I say "ooooh, you're big and tough aren't ya?" and pick her up. She's fine after I pick her up and she's in my hands.

The first thing I thought when reading your post was maybe she's going into shed. Did you check her eyes to see if they're cloudy?

Or maybe it's just that time of the month. :ohno: