Since ball pythons are generally just a super docile species, it doesn't seem like it (for most ball pythons).
But since the question is about snakes in general, I'd say it's true that some species may become more skittish if not handled often? If I don't handle even my dumeril's boa for over a week, I notice that she is more nervous the next time I reach in to take her out than she normally would be. That's my personal experience.
Same with a friend and her jungle carpet python. He became a bit snappy, and she became more afraid of taking him out. The longer she didn't take him out to handle, the snappier and more defensive he became, until she hardly is wiling to handle him at all. At this point, we haven't even talked about her JCP for almost a full year LOL.
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