I keep my mice in colonies, and never take the male out. I breed for maximum production, and so far this has worked best for me.
I got 1.5 and 1.6 colonies.
Never had a issue with cannibalism, exept a few first-time moms, but it's quite a while since i've noticed it.
The litters range from 15-22, with a peak at 24 babies so far, and have been steady at that for the last few years.
I replace the breeders at around 15 months.
At that time they usally have gone down to 10-12 babies a litter, and it's time to retire/get fed off
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