Well , one thing is that betadine is more of a bacteriostatic application whereas Neosporin being antibiotic is a bactericidal application. Betadine inhibits bacterial growth but Neosporin kills bacteria.Also betadine should be washed off of the reptile once the washing and cleaning has been done. Neosporin should be a very, very light application and never use the Neosporin that contains pain relief ingredients.