You should clean as best as you can as soon as you can. The only time I do not clean up immediately is when they are mating. If you are using natural substrate most spot clean then totally replace the substrate on a schedule. Hopefully someone will make a suggestion. I am an absolute clean freak with my animals because I am keeping so many in way closer conditions than they would ever live naturally. Only paper towels in my tubs and I do a full cleaning every time there is anything in the tub that could grow bacteria or mold. (poop, urates, blood)