Not sure about fire ants but we got ants every year in our house and that leads to spiders and then centipedes. One year we were killing something every day (old house we rent). I then invested in Ortho home defense and i respray every 4 months. We have not seen seen any insects besides Fruit flies in our home for the last 2 years. That includes the basement. This stuff is pretty strong so you will need to open widows for ventilation or leave the room while it settles because it will make you cough. Other than that its great!
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