Most of my ball pythons get held at least 2 times a week for spot cleaning and a quick look over. That being said, I very rarely take them out to handle for lengthy periods of time. I currently have about 90 reptiles, about 45 or so being ball pythons. If I am holding a snake to let them have a few minutes outside the enclosure, it is usually not one of my balls. Maybe a boa, carpet, antaresia, colubrid, etc.