I'd say about 3-4 times a week each, for the BP's. My CK girl I don't handle at all except to clean her cage - she has health issues, so I want to eliminate as much reason for stress as possible. My male CK I used to handle 3-4 times a week, but he's been self-brumating himself lately, and only just started to come out of it, so he hasn't been getting handled lately. I don't handle within a day of feeding, unless there's a mess that needs to be cleaned up, and I try not to handle the day before feeding to make sure they're not stressed.