Rats don't tend to go crazy like mice sometimes do. They are generally very good moms, and if you do get one that is not, just cull her and replace her with a better mom.
Likewise, if you get a male who injures or kills females/pups, cull him.
If you get chewers, cull them(the whole bin). In my experience, if a rat chews the bin, all the rats in that bin will end up chewing. Only keep rats that are tame, healthy, fast growing, large litters, etc. You'll end up with a healthy colony that will produce well for you.
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