Up the pray to the appropriate size and feed on a regular schedule, around every 7 days. It is best to do one large meal instead of multiple small meals. If you feed more than you handle Louie he is going to think it's always time for food. I had a somewhat aggressive ball python and occasionally if she looked as though she was going to strike me I wore a glove and rubbed her side to let her know I wasn't going to hurt her. Then I took the glove off and picked her up. Now she never associates my hand with food or a predator and she is very friendly!

Don't spray Louie or he will become scared of you which may cause him to become more defensive. I also find that tanks that open in the front instead of above the snake are less intimidating for them.