I am not a breeder, or have any knowledge of breeding anything (other than guinea pigs), but I don't think any hybridization should ever be done. If it wouldn't breed naturally in the wild under it's own power, then it should not be done through human interference. Hybrids tend to have issues. Donkey-Horse hybrids (mules) are sterile, lion-tiger hybrids have growth regulation problems that can lead to deformities, so who knows what kind of genetic misfits could be produced in snakes. Recently red fox-grey fox hybrids are becoming popular as "domestic foxes", then when they get older and start acting like a fox, people dump them in the wild. They usually don't survive, but if they do, they will probably mate with wild foxes and you'll have a bunch of silver and white foxes diluting the wild population.
Then to go a step further, if ball-retic or other large snake hybrids became super popular, it's only a matter of time until some of them get loose in say, Florida. Then what happens when you have a man-made ball-retic that breeds with a feral burm? Even if it happens by accident a feral burm-rock hybrid could exist. What happens if that snake has the same gene issue as the "ligers" and it never stops growing. All in all, IMO hybridization is always a bad idea.
Sorry about the rant
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