I've passed up on a couple amazing single-gene snakes. If it's a male, I take one on the chin, and pass.
I'm a hobby breeder, but I would like more bang for my buck, especially since I built my collection around a lot of combo females. If you had normal females and other single-gene females, I wouldn't really mind getting an awesome male morph.
I -might- be picking up a single-gene female later tonight, but I'm still sleeping on it and thinking about it some more.