I thought I'd point out that quarantine refers to keeping an animal in isolation from other animals while you wait to see if the animal has an illnesses. Isolation usually refers to an animal that has been confirmed as having an illness. I do at least three months, six months is ideal for new animals. The advised two week period of not handling the animal is to allow the animal to be more accumulated.

Being bitten is really not a big deal with ball pythons. I've been bitten a few times. You'll probably laugh when it happens. That said, don't feel bad if you're nervous about being bitten. Put on gardening gloves and a jacket if you have to. The snake doesn't care what you're wearing, it cares how you approach it. Be confident. Don't try to pick it up then withdraw then try to pick it up then withdraw then try to pick it up. That reads as a predator trying to figure out how to eat the ball python. Be confident. Approach it from behind its head, give it a quick stroke, then pick it up using your full hand to pick up the snake at its largest point. Also, some snakes are head shy. They just don't want their faces touched, their noses bopped, or their head stroked. If something does touch their head, they'll usually jerk their head away from the object that touched their head. This is a defensive behavior, not a hunting mode or aggressive behavior. Don't worry about the jerking movements, it's just a baby ball trying to figure everything out.

I don't handle my snakes every day. I don't think it's necessary to do that. You'll find a rhythm with yours.