Those enclosures do kind of sound too big, but if the snakes are eating, drinking, and spend the majority of their time hiding (constantly being out and 'pacing' the tank is a sign of stress) I wouldn't worry about it as long as you can keep the temp/humidity right.

If they are acting stressed, try a smaller enclosure. Adding in lots of fake plants to cover the floor also seems to help. How long were they acting funny in the smaller enclosures? It can take several weeks for BPs to get used to any new environment. But like I said, if they aren't acting stressed, you probably don't need to switch the enclosures.

A short amount of handling daily is fine. I like to handle at least every day/every other day (just not right after feeding) in order to check my snakes' health and catch any problems early on. If the snakes start acting stressed or refusing food, it's good to cut back on handling though.

Coming out when you enter the room is fairly normal. Even though they're well fed, they don't realize another rodent will magically appear in a few days so they're still looking for food.