Never put much thought into handling directly after a shed. People help snakes with bad sheds all the time (I've done this too) and the snakes don't seem to act any different than any other time.
As for handling during a shed cycle, most snakes will make it pretty clear to you that they would really rather not be handled. I generally don't unless it's for cleaning.
My baby Bp hasn't had a clean shed yet. I have to emmerse him in warm water for an hour each time.