Yes if not done responsibly, but it is safe if done responsibly as well.
It's about being educated and knowing how to properly feed live.
I feed 250 live preys a months (not counting hatchlings, that's a drop in a bucket compare to some) and have done so for 9 years with my breeders and holdbacks and NEVER had an issue.
The keys to success
Pre-scent the room bring the feeder near the enclosure 30 min prior to feeding.
Give food and water to the feeder if you purchased it from a store.
Do not stress the feeder.
Do not feed an oversized prey
Drop the feeder and remove if uneaten after 15 to 20 min