Look up videos on YouTube, they help a lot. Just have something to hold the rodent down at the neck and pull from the base of the tail upwards and towards the head until you hear and feel the neck break. It is instant but there will be some twitching, which is just nerve reactions. Mice have very small bones, so you don't have to yank the tail like you're starting a chainsaw . Just pull firmly while keeping pressure on the neck. I usually use a pencil to hold down a mouse neck (that is my pre killing mice only pencil lol) and a cleaning rod for rats since they are bigger and obviously a little harder to hold down. You can also Co 2 chamber the rodents if you need to do a lot of them at once.