It really depends on the animal. Vanilla, is going to do different things with different combos. Typically, the head pattern should look more blushed and softer colors throughout.
Here is a example of a Fire Spider http://www.worldofballpythons.com/morphs/fire-spider/
With the Vanilla gene
http://www.worldofballpythons.com/mo...pider-vanilla/
Vanilla and Fire really compliment each other in my opinion.
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