In ten years with sapphire, she didn't strike at me one time, no hissing either, and loki hasn't tried in the couple of weeks I've had him, so far so good. I'm not really afraid of the pain or anything from my first bite (I'm assuming I won't go unbitten forever) but I am slightly scared of the situation I guess. 1. I wouldn't like a food response bite because I would be worried about the snake harming itself trying to coil me, like by ripping out teeth. And 2. I wouldn't like a defensive bite because it means that I startled the snake, or it just doesn't trust me. I can't imagine there would be much physical pain, maybe from an angry adult, but juvenile snakes I'm guessing it's more of a pinch?