I think I should have specified, they can't sneeze or cough reflexively. But yeah, honestly, I would say better safe than sorry. If it's a large, open room like a living room, you're probably safe, but if it's someplace small and enclosed like a bedroom, do it elsewhere. I should note that crawling around MORE isn't necessarily a GOOD sign in ball pythons. They like to chill mostly, so being very active and restless is maybe your snake trying to tell you it's finding something uncomfortable.