And this is how the addiction begins...these things really should be called "crack" pythons due to their addictive nature. LOL
Queen Bee's are beautiful and if that's what you like then that's what you should plan to breed.
I started out loving Coral Glows and a lot of their combos so I got a CG male and picked up a Fire, Mojave, and Enchi girls to eventually pair him up with. My first project will be to try for a Coral Glow Fire.
I would say some questions to address would be around your setup. Are you planning on using tubs or tanks? Tanks can start to get costly and take up a lot of your time too with cleaning etc. Tub and tub racks will make life a lot easier on you but don't look as nice in your house, if that's a concern? Another thing to consider is how are you going to handle the snakes you breed that you don't want to keep? If you get your male spider you'll need a Lesser Pastel female to produce a Queen Bee, this will give you a 1/8 chance of hitting your Queen Bee but it has equal odds of producing normals, pastels, lesser's, spiders, etc.
Others will most certainly just in with other comments and suggestions so I'll leave it here before my post becomes a book.