This. If your vet just pushed Baytril (the most common antibiotic) because your snake had an RI, and there was no culture done, then it's not time to give up yet. Baytril has been around long enough that most RI's are resistant to it.
Not only that, but you really need to know the cause ASAP as well. Not only could your other animals be at risk, but if you sell any of them, even if they're not showing symptoms yet, they could carry the disease to other collections. Some diseases have very long incubation periods.