Depends on the snake. Each one is different. I got lucky I guess because both my big BCI girl and my little pied BP girl like to be out and about. Well my BCI likes it a lot more as she loves to sit on me while I wander around doing stuff and she will try and climb onto anything I get near...trees, rain gutters, deck railings, anything she can stretch to and inspect. My little pied girl though is more content to just make a big circle on my stomach/chest and just relax there for hours while I watch tv once in awhile shifting her head position. As for handling, I pretty much pet or take my BCI out daily and leave her cage door open most of the evening while im watching tv as she loves to just hang out. The pied girl is usually handled every other day usually in the evenings as that seems to be when she is happiest being out. During the day, she will usually curl up and throw a coil over her head like she wants to sleep if I take her out and let her sit on me, or she tries and find a dark spot on the couch to curl up in. You learn to read your snakes and know when they have had enough and want back in the cage or to be left alone and then you do just that, leave them alone. So bottom line, there is no "too much handling". It's what your snake accepts as its limit of interaction with you. And all this only applies if your snake is already settled in, eating and you have him/her for months. If it is a new snake, then don't handle for a week or until its eaten 3 meals with no problem. Then work in 10-15 min intervals daily or every other day while watching how the snake reacts and adjusting accordingly.