That depends on you, the snake, and the environment. When you first get a snake, it should have at least a week hands off to settle in. After that, start with SHORT handling sessions (10-15 minutes) and build your way up. Now some snakes are naturally nervous and stress easy, and some are super chill. As you get to know each snake, you'll figure out their personalities and which ones are better suited to more handling. I like to handle them each at least once or twice a week so I can give them a better inspection than just looking in their tubs, and the ones that are more relaxed/fun to handled get held more often. And of course, always remember to give them a couple of days off after they eat and leave them alone when they're in shed.