Many genetic problems in domestic animals are due to inbreeding. That is certainly true in dogs and mice.
I do not believe that the wobble in spider ball pythons is due to inbreeding. As spider bred to normal produces both spider and normal babies, the temptation has always been to breed a spider male to multiple normal females, for maximum return on investment. There was only one imported spider, so that first mating had to have been to one or more normals. And World of Ball Pythons gives 1999 for the first produced date. That is only 16 years ago. I do not know whether that imported royal is still alive, but its offspring could easily still be alive and breeding. Both outbreeding and inbreeding can produce train wrecks from a minimal wobble parent. But selective breeding would be required to produce lines with minimal wobble, and that requires inbreeding. Choosing two spiders for parents tells us that both have minimal wobble. If one parent is a normal sibling, there is no way to be sure whether or not it has the additional genes for minimal wobble. Such breeding might throw some light on the homozygous spider question, but that's a beneficial side effect to the project.
I do not know whether is possible to produce a totally wobble-free spider ball python. But nothing ventured, nothing gained.
Covering the eyes or the labial pits would eliminate information from those sense organs. If a part of the brain misinterprets such information and thus causes the wobble, then cutting off the information to that part of the brain could reduce or eliminate the wobble. I think it is interesting that everyone says the wobble is worst at feeding time, when eye and labial pit information is most depended on.
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