when you go to pick him up don't go straight for his face and pick him up gently, once you have him out its smooth sailing from there. if he hisses at you its just him being a little scared and if he strikes it won't hurt too bad, more scary than anything. just go for it, the only way to become 100% comfortable with picking him up out of his enclosure is just to do it multiple times and for him to get used to being handled.