Do you mean in the same room? because I leave both of my snakes in the tank in my apartment with my cat around. My apartment is one giant room so it's impossible to separate them. Luckily, I live at the boarding school that I work at, so I'm never away from my apartment for more than 4 hours. My snakes hide in their hides all day long and it is rare that I see my cat paying any attention to the snake tanks