Snakes often make noises - especially when they are being held or messed with - that emanate from the glottis and the nares. These are usually the expulsion of breath due to stress and they can sound like a wheeze.
Occasional situational whistling/crackling/static from the glottis is normal, and is a by-product of the shape of the glottis X the rush of air forced through it. It is completely normal and is nothing to worry about - especially if he is doing it when you are screwing with him.