One shot should not clear up a RI. Snakes take longer to respond to meds and a RI is not easy to beat. Usually a couple to a few weeks of shots are needed to fully treat it. A snake with a with a "advanced RI" is not going to be better after one shot.
When I got my GTP he had a RI. It was in the early stages but still took three weeks to get him back on track and kick the RI.
What are the signs of RI that you are observing?
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