For my large tanks I just had a spray bottle with 10% bleach solution. I first sprayed with just water to get little bits of dirt/ substrate out and wiped clean. Then sprayed with the bleach solution and I had a little brush to get in the corners and any nooks and crannies. Let sit for 10 minutes, wipe out, and do a couple spray rinses with plain waiter and wipe dry. Then air it out for about 10 minutes or until there is no more bleach smell.