Yes, DS is a genetic abnormality. Yes, scaleless ball pythons are a genetic abnormality. However, DS is associated with physical and intellectual disability. Scaleless ball pythons, despite their obvious physical differences, do not (in my understanding) behave differently than any other ball python morph. They eat well, shed well, poop well, and move well. To put it simply, they're thriving.
We, as responsible hobbyists and breeders, do not knowingly breed for snakes with known physical or intellectual disabilities that impact their quality of life.