Being in the same room has nothing to do with it.
It may have something to do with the enormous tanks.
Could be your husbandry (Temps, humidity, setup)
Also could be the prey size.

From the size you listed, he should be on mediums and she should be on Med-LG using the Layne Labs Rat scale.
http://www.laynelabs.com/frozen-rats

So get the info on your husbandry and maybe some pics and I am sure someone can help out. But snakes go on food strikes frequently it seems...