I usually handle my Bps for no more than half an hour each. I would avoid keeping them out for longer than 45 minutes at a time, because it could start to get stressful. If I notice one of them trying to get into the crevices of the couch or chair I'm in, I put that snake back in his cage. If one of the snakes is slithering around his cage madly, he gets taken out for awhile. I only handle them a few hours a week though, when the boyfriend and I are sitting watching TV (which is a very rare thing, since we both work!)