I think it really does depend on the animal.

Kaa, an adult male I have, loves to be out and is very calm whenever I pick him up or climbs up my arm and will proceed to eat after handling with no issue. I still try to limit handling to 2-3 times a week and no more than 30 minutes, and I give a day off before feeding.

The hatchling I just got is more skittish, but he is a hatchling. Neither of them have ever hissed or bitten.

The first snake I thought of purchasing became very very stressed about handling. Hissed, attempted to bite me and the employee, and moved a lot faster than one would think a ball python could move trying to get away. That particular snake had been neglected by the owner and hadn't been handled in years, however. I do think that removing an animal when they are hiding still adds an amount of stress, no matter what the disposition of your animal is.