Unless he is showing outward signs of an infection, leave him alone. Don't try to open his mouth, don't rearrange his hides, don't pick him up, don't bathe him, just don't.
Snakes often make noises - especially when they are being held or messed with - that emanate from the glottis and the nares. These are usually the expulsion of breath due to stress and they can sound like a wheeze.
Occasional situational whistling/crackling/static from the glottis is normal, and is a by-product of the shape of the glottis X the rush of air forced through it. It is completely normal and is nothing to worry about - especially if he is doing it when you are screwing with him.
Contrary to popular opinion, ball pythons can take an occasional dip in temperatures. What they can't take is owners who are always screwing with them. Stress is definitely more hazardous to that animals health than a dip or two below "optimum" temperature.
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