I see no reason to treat an inbred pairing any different. If issues become common, stop breeding that pair, whether they be brother and sister or 50 generations removed. If there are no issues, why the heck wouldn't you keep going? Genetic diversity is good for adapting if the status quo changes, such as a disease or environmental change. Line breeding is the way to go for a strong animal, assuming you get the right parts together.
Humans find ways to cope with the negative traits and survive, just about every other species just lets that animal die, so our gene pool filled with negative genes that should of took out some of our lines out a long long time ago. Damn developed brain screwing up our gene pool.
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